منابع مشابه
Metastatic bone disease
OBJECTIVES Guidelines for the management of patients with metastatic bone disease (MBD) have been available to the orthopaedic community for more than a decade, with little improvement in service provision to this increasingly large patient group. Improvements in adjuvant and neo-adjuvant treatments have increased both the number and overall survival of patients living with MBD. As a consequenc...
متن کاملMetastatic bone disease
Metastatic bone disease is the most common malignancy of bone, it is estimated that 70% of all malignant bone tumors are metastatic in origin. At autopsy it has been reported between 30 to 85% of patients who die from cancer show occult skeletal metastases. Bone is the third most common site of metastatic process after lung and liver. 80% of metastatic bone disease arise from Ca of breast, pros...
متن کاملBisphosphonates and metastatic bone disease.
Malignant bone disease is a frequent complication of several common solid tumours including breast, lung, prostate and renal cancer. A greater understanding of tropic bone tumour cells, especially the understanding of those properties which lead to their successful growth within the bone microenvironment is the first step to devise innovative approaches. Bone metastases are generally characteri...
متن کاملMetastatic bone disease: diagnosis, evaluation, and treatment.
The management of bone metastases has changed considerably over the past decade, with the improved longevity of cancer patients, the advent of bisphosphonates, and the availability of other new treatment modalities. Of primary importance is the systematic establishment of the diagnosis of metastasis before treatment, which avoids improper management of primary bone malignancies and optimizes on...
متن کاملSRC inhibitors in metastatic bone disease.
Src tyrosine kinase was the first gene product shown to have an essential function in bone using recombinant DNA technology after its expression was knocked out in mice approximately 15 years ago. Since then, our understanding of the regulation of bone catabolism has advanced significantly with the identification of other key enzymes that regulate osteoclast formation, activation, and survival ...
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ژورنال
عنوان ژورنال: Medical Journal of Indonesia
سال: 2004
ISSN: 2252-8083,0853-1773
DOI: 10.13181/mji.v13i2.141